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Contribution of hippocampal and extra-hippocampal NR2B-containing NMDA receptors to performance on spatial learning tasks.

Abstract:

Controversy revolves around the differential contribution of NR2A- and NR2B-containing NMDA receptors, which coexist in principal forebrain neurons, to synaptic plasticity and learning in the adult brain. Here, we report genetically modified mice in which the NR2B subunit is selectively ablated in principal neurons of the entire postnatal forebrain or only the hippocampus. NR2B ablation resulted in smaller NMDA receptor-mediated EPSCs with accelerated decay kinetics, as recorded in CA1 pyrami...

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Publication status:
Published

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Journal:
Neuron
Volume:
60
Issue:
5
Pages:
846-860
Publication date:
2008-12-05
DOI:
EISSN:
1097-4199
ISSN:
0896-6273
URN:
uuid:7a36b643-0d96-4031-aad8-27a3fb9263c8
Source identifiers:
317
Local pid:
pubs:317

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