Extent to which pulmonary vascular responses to PCO2 and PO2 play a functional role within the healthy human lung.

Journal article

Regional blood flow in the lung is known to be influenced by the alveolar PCO2 and alveolar PO2. For the healthy lung, the extent to which this influence is of functional importance in limiting heterogeneity in alveolar gas composition by matching regional perfusion (q) to regional ventilation (v) remains unclear. To address this issue, the efficiency of regulation (E) was defined as the percent correction to an initial perturbation in regional alveolar gas composition generated by the pulmon...

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Authors: Dorrington, K; Balanos, G; Talbot, N; Robbins, P

• Publication status: Published
• Journal: Journal of applied physiology (Bethesda, Md. : 1985)
• Volume: 108
• Issue: 5
• Pages: 1084-1096
• Publication date: 2010-05-01
• DOI: 10.1152/japplphysiol.90963.2008
• EISSN: 1522-1601
• ISSN: 8750-7587
• Language: English
• Keywords: Pulmonary Circulation; Adult; Hypercapnia; Echocardiography, Doppler; Partial Pressure; Carbon Dioxide; Ventilation-Perfusion Ratio; Young Adult; Oxygen; Reference Values; Female; Male; Models, Cardiovascular; Heart Rate; Lung; Hypocapnia; Hyperventilation; Stroke Volume; Adaptation, Physiological; Regional Blood Flow; Time Factors; Humans