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Adjunctive rifampicin to reduce early mortality from Staphylococcus aureus bacteraemia: the ARREST RCT

Abstract:

Background: Around 12,500 cases of Staphylococcus aureus bacteraemia occur each year in the United Kingdom, with an associated mortality of about 30%, yet the evidence guiding optimum management is poor. We hypothesise that adjunctive rifampicin will enhance killing of Staphylococcus aureus early in the course of antibiotic treatment of bacteraemia, sterilise infected foci and blood faster, and thereby reduce the risk of dissemination, metastatic infection and death. Design: A randomised, bl...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.3310/hta22590

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Institution:
University of Oxford
Division:
Medical Sciences
Department:
NDM
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Institution:
University of Oxford
Division:
Medical Sciences
Department:
NDM
Szubert, AJ More by this author
Saramango Concalves, P More by this author
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Grant:
Health Technology Assessment Programme; 10/104/2
Publisher:
NIHR Journals Library Publisher's website
Journal:
Health Technology Assessment Journal website
Volume:
22
Issue:
59
Publication date:
2018-11-01
Acceptance date:
2018-07-04
DOI:
EISSN:
2046-4924
ISSN:
1366-5278
Pubs id:
pubs:864629
URN:
uri:7a2a26cf-5ceb-4067-a2a3-3a8b2c58a19d
UUID:
uuid:7a2a26cf-5ceb-4067-a2a3-3a8b2c58a19d
Local pid:
pubs:864629

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