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Thesis

Targeting the PI3K/mTOR and ATR/Chk1 pathways to improve radiation efficacy for cancer therapy

Abstract:

The purpose of the present thesis was to better understand the effect of targeting key biological mechanisms in order to improve radiotherapy response. Two important and distinct pathways were targeted using novel agents: (1) the phosphoinoside-3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway; (2) the ataxia telangiectasia-mutated-Rad3-related (ATR)/Chk1 pathway. The role of the PI3K/mTOR signalling pathway in tumour radiosensitivity and tumour microenvironment (TME) was ex...

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Institution:
University of Oxford
Oxford college:
Linacre College
Department:
Medical Sciences Division - Radiation,Oncology and Biology
Role:
Author

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Role:
Supervisor
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
Language:
English
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