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Haemophilus influenzae type b vaccine failure in children is associated with inadequate production of high-quality antibody.

Abstract:

BACKGROUND: Despite the excellent immunogenicity of Haemophilus influenzae type b (Hib) conjugate vaccines, breakthrough cases of Hib disease still affect a small proportion of vaccinated children in the United Kingdom. We performed a retrospective study to compare the avidity of antibody directed against the Hib polysaccharide capsule (PRP) in children who experienced Hib vaccine failure in the United Kingdom among 3 historical cohorts and with age-matched healthy control subjects. METHODS:...

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Publication status:
Published

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Publisher copy:
10.1086/524668

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Journal:
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Volume:
46
Issue:
2
Pages:
186-192
Publication date:
2008-01-05
DOI:
EISSN:
1537-6591
ISSN:
1058-4838
URN:
uuid:7a238db6-202b-4be7-95ba-76f732c1cdd1
Source identifiers:
119113
Local pid:
pubs:119113

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