IL-17A exacerbates fibrosis by promoting the proinflammatory and profibrotic function of orbital fibroblasts in TAO

Journal article

Context: The development of thyroid-associated ophthalmopathy (TAO) is associated with self-immune dysfunction. Recent findings in TAO and Graves' disease indicate that IL-17A may also be involved in the autoimmunity of TAO.

Objective: We sought to investigate the pathogenic function of IL-17A-producing T cells in TAO.

Design/Setting/Participants: Blood samples and orbital fibroblasts (OFs) were collected from TAO patients ...

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Authors: Fang, S; Huang, Y; Wang, S; Zhang, Y; Luo, X

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Oxford University Press
• Journal: Journal of Clinical Endocrinology and Metabolism
• Volume: 101
• Issue: 8
• Pages: 2955-2965
• Publication date: 2016-08-01
• Acceptance date: 2016-05-16
• DOI: 10.1210/jc.2016-1882
• EISSN: 1945-7197
• ISSN: 0021-972X
• Language: English
• Keywords: FFR