Journal article
Diversely substituted quinolines via rhodium-catalyzed alkyne hydroacylation
- Abstract:
- The Rh-catalyzed hydroacylative union of aldehydes and o-alkynyl anilines leads to 2-aminophenyl enones, and onwards to substituted quinolines. The mild reaction conditions employed in this chemistry result in a process that displays broad functional group tolerance allowing the preparation of diversely substituted quinolines in high yields. Extension to the use of o-alkynyl nitro arenes as substrates, leads to 2-nitrochalcones, from which both quinolines and quinoline N-oxides can be accessed.>
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 766.2KB, Terms of use)
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- Publisher copy:
- 10.1021/acs.orglett.6b00390
Authors
- Publisher:
- American Chemical Society
- Journal:
- Organic Letters More from this journal
- Volume:
- 18
- Issue:
- 7
- Pages:
- 1562–1565
- Publication date:
- 2016-03-14
- Acceptance date:
- 2016-02-09
- DOI:
- ISSN:
-
1523-7060
- Pubs id:
-
pubs:609560
- UUID:
-
uuid:7a18769c-7289-4d6f-8924-d8ef1e69f121
- Local pid:
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pubs:609560
- Source identifiers:
-
609560
- Deposit date:
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2016-03-11
Terms of use
- Copyright holder:
- American Chemical Society
- Copyright date:
- 2016
- Notes:
- Copyright © 2016 American Chemical Society. This is an open access article published under a Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
- Licence:
- CC Attribution (CC BY)
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