Journal article
Disruption of inhibitory G-proteins mediates a reduction in atrial beta-adrenergic signaling by enhancing eNOS expression.
- Abstract:
-
OBJECTIVE: Cardiac parasympathetic nerve activity is reduced in most cardiovascular disease states, and this may contribute to enhanced cardiac sympathetic responsiveness. Disruption of inhibitory G-proteins (Gi) ablates the cholinergic pathway and increases cardiac endothelial nitric oxide (NO) synthase (eNOS) expression, suggesting that NO may offset the impaired attenuation of beta-adrenergic regulation of supraventricular excitability. To test this, we investigated the role of endogenous ...
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- Publication status:
- Published
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- Publisher copy:
- 10.1016/j.cardiores.2005.04.034
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Authors
Bibliographic Details
- Journal:
- Cardiovascular research
- Volume:
- 67
- Issue:
- 4
- Pages:
- 613-623
- Publication date:
- 2005-09-01
- DOI:
- EISSN:
-
1755-3245
- ISSN:
-
0008-6363
- Source identifiers:
-
104969
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:104969
- UUID:
-
uuid:79f7396c-63a8-4289-84e4-1dbc04305003
- Local pid:
- pubs:104969
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2005
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