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Hedgehog signaling via a calcitonin receptor-like receptor can induce arterial differentiation independently of VEGF signaling in zebrafish.

Abstract:

Multiple signaling pathways control the specification of endothelial cells (ECs) to become arteries or veins during vertebrate embryogenesis. Current models propose that a cascade of Hedgehog (Hh), vascular endothelial growth factor (VEGF), and Notch signaling acts instructively on ECs to control the choice between arterial or venous fate. Differences in the phenotypes induced by Hh, VEGF, or Notch inhibition suggest that not all of the effects of Hh on arteriovenous specification are mediate...

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Journal:
Blood
Volume:
120
Issue:
2
Pages:
477-488
Publication date:
2012-07-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:79e9d9d3-309e-43eb-8581-99502aff950a
Source identifiers:
344611
Local pid:
pubs:344611

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