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Quantifying infarct growth and secondary injury volumes: comparing multimodal image registration measures

Abstract:
Background and Purpose—Lesion expansion in the week after acute stroke involves both infarct growth (IG) and anatomic distortion (AD) because of edema and hemorrhage. Enabling separate quantification would allow clinical trials targeting these distinct pathological processes. We developed an objective and automated approach to quantify these processes at 24 hours and 1 week. Methods—Patients with acute ischemic stroke were scanned at presentation, 24 hours, ... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1161/STROKEAHA.118.020788

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; RDM - Investigative Medicine Division
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Sheerin, F More by this author
Jenkinson, M More by this author
Kennedy, J More by this author
Centre of Excellence for Personalized Healthcare More from this funder
Engineering and Physical Sciences Research Council More from this funder
Oxford University Clinical Academic Graduate School More from this funder
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Publisher:
American Heart Association Publisher's website
Journal:
Stroke Journal website
Volume:
49
Issue:
7
Pages:
1647-1655
Publication date:
2018-06-12
Acceptance date:
2018-05-14
DOI:
EISSN:
1524-4628
ISSN:
0039-2499
Pubs id:
pubs:857032
URN:
uri:79e6ec06-2fe1-4a90-821e-600fa297dc05
UUID:
uuid:79e6ec06-2fe1-4a90-821e-600fa297dc05
Local pid:
pubs:857032

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