K(Ca) channel blockers reveal hyperpolarization and relaxation to K+ in rat isolated mesenteric artery.

Journal article

Raising extracellular K+ concentration ([K+](o)) around mesenteric resistance arteries reverses depolarization and contraction to phenylephrine. As smooth muscle depolarizes and intracellular Ca(2+) and tension increase, this effect of K+ is suppressed, whereas efflux of cellular K+ through Ca(2+)-activated K+ (K(Ca)) channels is increased. We investigated whether K+ efflux through K(Ca) suppresses the action of exogenous K+ and whether it prestimulates smooth muscle Na(+)-K(+)-ATPase. Under ...

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Authors: Dora, K; Ings, N; Garland, C

• Publication status: Published
• Journal: American journal of physiology. Heart and circulatory physiology
• Volume: 283
• Issue: 2
• Pages: H606-H614
• Publication date: 2002-08-01
• DOI: 10.1152/ajpheart.01016.2001
• EISSN: 1522-1539
• ISSN: 0363-6135
• Language: English
• Keywords: Vasodilation; Sodium-Potassium-Exchanging ATPase; Animals; Potassium; Rats; Rats, Wistar; Potassium Channel Blockers; Vasoconstrictor Agents; Phenylephrine; Apamin; Charybdotoxin; Peptides; Pressure; Mesenteric Arteries; Potassium Channels, Calcium-Activated; Enzyme Activation; Drug Combinations; Male; Electrophysiology