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Alpha-synuclein release by neurons activates the inflammatory response in a microglial cell line

Abstract:

The neurodegenerative process in Parkinson's disease (PD) is accompanied by the presence of a neuroinflammatory response, which has been suggested as one of the principal components involved in PD progression.In this report we assessed the inflammatory potential of alpha-synuclein, a protein central to PD pathogenesis, released by neurons on the mouse microglia cell line BV-2. BV-2 cells were treated with conditioned medium isolated from normal SH-SY5Y cells and clones that over-express WT or...

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Authors


Alvarez-Erviti, L More by this author
Richardson, J More by this author
Cooper, JM More by this author
Journal:
Neuroscience Research
Volume:
69
Issue:
4
Pages:
337-342
Publication date:
2011-04-05
DOI:
ISSN:
0168-0102
URN:
uuid:79b0b2f7-0b44-4410-8b01-37c1b4cb5e32
Source identifiers:
124619
Local pid:
pubs:124619

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