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Enhanced K +-channel-mediated endothelium-dependent local and conducted dilation of small mesenteric arteries from ApoE -/- mice

Abstract:

AimsAgonists that evoke smooth muscle cell hyperpolarization have the potential to stimulate both local and conducted dilation. We investigated whether the endothelium-dependent vasodilators acetylcholine (ACh) and SLIGRL stimulated conducted dilation and whether this was altered by deficiency in apolipoprotein E (ApoE -/-).Methods and resultsIsolated mesenteric arteries were cannulated, pressurized, and precontracted with phenylephrine. Agonists were either added to the bath to study local d...

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Publisher copy:
10.1093/cvr/cvr181

Authors


Beleznai, T More by this author
Douglas, G More by this author
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Journal:
Cardiovascular Research
Volume:
92
Issue:
2
Pages:
199-208
Publication date:
2011-11-01
DOI:
EISSN:
1755-3245
ISSN:
0008-6363
URN:
uuid:79a70642-5fab-448c-89d0-ced8d6b7e9c2
Source identifiers:
193012
Local pid:
pubs:193012

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