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Dexamethasone, cerebrospinal fluid matrix metalloproteinase concentrations and clinical outcomes in tuberculous meningitis.

Abstract:

BACKGROUND: Adjunctive dexamethasone reduces mortality from tuberculous meningitis, but how it produces this effect is not known. Matrix metalloproteinases (MMPs) are important in the immunopathology of many inflammatory CNS diseases thus we hypothesized that that their secretion is important in TBM and might be influenced by dexamethasone. METHODOLOGY/PRINCIPAL FINDINGS: The kinetics of cerebrospinal fluid (CSF) MMP and tissue inhibitors of MMPs (TIMPs) concentrations were studied in a subse...

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Publication status:
Published

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Publisher copy:
10.1371/journal.pone.0007277

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Institution:
University of Oxford
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine
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Institution:
University of Oxford
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Institution:
University of Oxford
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Medical Research Council More from this funder
Wellcome Trust More from this funder
Hammersmith Hospital Special Trustees More from this funder
NIHR Biomedical Research Centre More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PloS one Journal website
Volume:
4
Issue:
9
Pages:
Article: e7277
Publication date:
2009
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
URN:
uuid:79a4ac79-dfa4-40a6-8bfd-19e909d670ef
Source identifiers:
92790
Local pid:
pubs:92790

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