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A Role for E1B-AP5 in ATR Signaling Pathways during Adenovirus Infection

Abstract:

E1B-55K-associated protein 5 (E1B-AP5) is a cellular, heterogeneous nuclear ribonucleoprotein that is targeted by adenovirus (Ad) E1B-55K during infection. The function of E1B-AP5 during infection, however, remains largely unknown. Given the role of E1B-55K targets in the DNA damage response, we examined whether E1B-AP5 function was integral to these pathways. Here, we show a novel role for E1B-AP5 as a key regulator of ATR signaling pathways activated during Ad infection. E1B-AP5 is recruite...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1128/JVI.00170-08

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology, CRUK/MRC Ox Inst for Radiation Oncology
Bruton, RK More by this author
Stewart, GS More by this author
Taylor, AMR More by this author
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Publisher:
American Society for Microbiology Publisher's website
Journal:
Journal of Virology Journal website
Volume:
82
Issue:
15
Pages:
7640-7652
Publication date:
2008-05-14
Acceptance date:
2008-04-30
DOI:
ISSN:
0022-538X
URN:
uuid:7993e8b2-e94d-4b2e-ab5d-f68a329b6823
Source identifiers:
629195
Local pid:
pubs:629195
Keywords:

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