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Influence of Na/Ca exchange stoichiometry on model cardiac action potentials.

Abstract:
Cardiac action potential simulations were done with the stoichiometry of the Na/Ca exchanger set a 4: 1. Using the Hilgemann-Noble (1987) model, this stoichiometry reduces the resting potential unless regulation by intracellular calcium is incorporated. The K(d) required for such regulation is consistent with current experimental estimates of this parameter.
Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Journal:
Annals of the New York Academy of Sciences
Volume:
976
Issue:
1
Pages:
133-136
Publication date:
2002-11-05
DOI:
EISSN:
1749-6632
ISSN:
0077-8923
URN:
uuid:799148b6-63ca-4668-b8a4-77a049b72071
Source identifiers:
237189
Local pid:
pubs:237189

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