Journal article
The molecular dissection of TRIM25’s RNA-binding mechanism provides key insights into its antiviral activity
- Abstract:
-
TRIM25 is an RNA-binding ubiquitin E3 ligase with central but poorly understood roles in the innate immune response to RNA viruses. The link between TRIM25’s RNA binding and its role in innate immunity has not been established. Thus, we utilized a multitude of biophysical techniques to identify key RNA-binding residues of TRIM25 and developed an RNA-binding deficient mutant (TRIM25-m9). Using iCLIP2 in virus-infected and uninfected cells, we identified TRIM25’s RNA sequence and structure spec...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Publisher copy:
- 10.1038/s41467-024-52918-x
Authors
Bibliographic Details
- Publisher:
- Nature Research
- Journal:
- Nature Communications More from this journal
- Volume:
- 15
- Issue:
- 1
- Article number:
- 8485
- Publication date:
- 2024-10-01
- Acceptance date:
- 2024-09-23
- DOI:
- EISSN:
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2041-1723
Item Description
- Language:
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English
- Source identifiers:
-
2299947
- Deposit date:
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2024-10-01
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