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Journal article

Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis.

Abstract:

Apoptosis is a key tumor suppression mechanism that can be initiated by activation of the proapoptotic factor Bax. The Ku70 DNA end-joining protein has recently been shown to suppress apoptosis by sequestering Bax from mitochondria. The mechanism by which Bax is regulated remains unknown. Here, we identify eight lysines in Ku70 that are targets for acetylation in vivo. Five of these, K539, K542, K544, K533, and K556, lie in the C-terminal linker domain of Ku70 adjacent to the Bax interaction ...

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Publication status:
Published

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Journal:
Molecular cell
Volume:
13
Issue:
5
Pages:
627-638
Publication date:
2004-03-05
DOI:
EISSN:
1097-4164
ISSN:
1097-2765
URN:
uuid:7988c853-6462-484a-b61a-ae22b0e0cd9b
Source identifiers:
10497
Local pid:
pubs:10497

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