Increased frequencies of CD4+ CD25(high) regulatory T cells in acute dengue infection.

Journal article

Dengue virus infection is an increasingly important tropical disease, causing 100 million cases each year. Symptoms range from mild febrile illness to severe hemorrhagic fever. The pathogenesis is incompletely understood, but immunopathology is thought to play a part, with antibody-dependent enhancement and massive immune activation of T cells and monocytes/macrophages leading to a disproportionate production of proinflammatory cytokines. We sought to investigate whether a defective populatio...

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Authors: Lühn, K; Simmons, C; Moran, E; Dung, N; Chau, T

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Rockefeller University Press
• Journal: JournalName
• Volume: 204
• Issue: 5
• Pages: 979-985
• Publication date: 2007-04-23
• Acceptance date: 2007-03-21
• DOI: 10.1084/jem.20061381
• EISSN: 1540-9538
• ISSN: 0022-1007
• Pmid: 17452519
• Language: English
• Keywords: Vietnam; Cytokines; SBTMR; Child; Forkhead Transcription Factors; Journal Article; Humans; Interleukin-10; Research Support, Non-U.S. Gov't; T-Lymphocytes, Regulatory; Flow Cytometry; Comparative Study; T-Lymphocyte Subsets; Adult; Dengue