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Nicotine replacement in abstinent smokers improves cognitive withdrawal symptoms with modulation of resting brain network dynamics.

Abstract:

Symptoms of cognitive impairment during smoking withdrawal can be ameliorated by nicotine replacement. To define brain mechanisms contributing to this therapeutic effect, we conducted a functional connectivity analysis of resting-state fMRI in 17 abstinent smokers following nicotine replacement in a double-blind, placebo-controlled, crossover design. We found that individual differences in cognitive withdrawal symptom improvements after nicotine replacement were associated with increased inve...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Beckmann, CF More by this author
Matthews, PM More by this author
Durcan, MJ More by this author
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Journal:
NeuroImage
Volume:
52
Issue:
2
Pages:
590-599
Publication date:
2010-08-05
DOI:
EISSN:
1095-9572
ISSN:
1053-8119
URN:
uuid:7966365f-6939-471a-95d7-d64400e11c6b
Source identifiers:
375476
Local pid:
pubs:375476

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