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Journal article

High-density lipoproteins retard the progression of atherosclerosis and favorably remodel lesions without suppressing indices of inflammation or oxidation.

Abstract:

OBJECTIVE: Protective properties of high-density lipoproteins (HDL) may include reverse cholesterol transport and suppression of oxidation and inflammation. These were investigated in vivo, as were the effects of HDL on the characteristics of atherosclerotic lesions. METHODS AND RESULTS: Male apolipoprotein E knockout (apoE-/-) and apoE-/- mice expressing human apolipoprotein AI (hAI/apoE-/-) were studied up to 20 weeks after commencing a high-fat diet. Plasma HDL cholesterol was twice as hi...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, RDM Cardiovascular Medicine
Role:
Author
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Journal:
Arteriosclerosis, thrombosis, and vascular biology
Volume:
24
Issue:
10
Pages:
1904-1909
Publication date:
2004-10-05
DOI:
EISSN:
1524-4636
ISSN:
1079-5642
URN:
uuid:7956dbb3-e672-47fd-badb-cc47352fc4e4
Source identifiers:
163153
Local pid:
pubs:163153

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