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Thesis

Patterns of selective constraint across the mouse and human genomes

Abstract:

Understanding how genetic variation affects organism phenotype and fitness is a fundamental question in biology with implications for biomedical research. Constrained genomic loci (i.e. loci under selective constraint) are depleted of variation due to negative selection and are inferred to be functionally important to organism fitness. Recent sequencing in human populations has allowed researchers to make contemporary estimates of selective constraint across the genome. These estimates pro...

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Division:
MSD
Role:
Author

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Supervisor
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Supervisor
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Deposit date:
2022-08-19

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