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A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease.

Abstract:

Alzheimer's disease (AD) involves progressive accumulation of amyloid β-peptide (Aβ) and neurofibrillary pathologies, and glucose hypometabolism in brain regions critical for memory. The 3xTgAD mouse model was used to test the hypothesis that a ketone ester-based diet can ameliorate AD pathogenesis. Beginning at a presymptomatic age, 2 groups of male 3xTgAD mice were fed a diet containing a physiological enantiomeric precursor of ketone bodies (KET) or an isocaloric carbohydrate diet. The res...

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Publication status:
Published

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Journal:
Neurobiology of aging
Volume:
34
Issue:
6
Pages:
1530-1539
Publication date:
2013-06-05
DOI:
EISSN:
1558-1497
ISSN:
0197-4580
URN:
uuid:793630f2-451f-49da-be65-0d3d1e5cc34a
Source identifiers:
371477
Local pid:
pubs:371477

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