The crystal structure of E. coli pantothenate synthetase confirms it as a member of the cytidylyltransferase superfamily.
BACKGROUND: Pantothenate synthetase (EC 126.96.36.199) is the last enzyme of the pathway of pantothenate (vitamin B(5)) synthesis. It catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction. RESULTS: We describe the overexpression, purification, and crystal structure of recombinant pantothenate synthetase from E. coli. The structure was solved by a selenomethionine multiwavelength anomalous dispersion experiment and refined against native data to a final R(cryst) of 22...Expand abstract
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