- Abstract:
-
We performed a meta-analysis of five genome-wide association studies to identify common variants influencing colorectal cancer (CRC) risk comprising 8,682 cases and 9,649 controls. Replication analysis was performed in case-control sets totaling 21,096 cases and 19,555 controls. We identified three new CRC risk loci at 6p21 (rs1321311, near CDKN1A; P = 1.14 × 10(-10)), 11q13.4 (rs3824999, intronic to POLD3; P = 3.65 × 10(-10)) and Xp22.2 (rs5934683, near SHROOM2; P = 7.30 × 10(-10)) This brin...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1038/ng.2293
-
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- Journal:
- Nature genetics
- Volume:
- 44
- Issue:
- 7
- Pages:
- 770-776
- Publication date:
- 2012-07-05
- DOI:
- EISSN:
-
1546-1718
- ISSN:
-
1061-4036
- URN:
-
uuid:79237dae-0987-484a-9f90-233fdbe7a97a
- Source identifiers:
-
334641
- Local pid:
- pubs:334641
- Language:
- English
- Keywords:
- Copyright date:
- 2012
Journal article
Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk.
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