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Tension directly stabilizes reconstituted kinetochore-microtubule attachments.

Abstract:

Kinetochores are macromolecular machines that couple chromosomes to dynamic microtubule tips during cell division, thereby generating force to segregate the chromosomes. Accurate segregation depends on selective stabilization of correct 'bi-oriented' kinetochore-microtubule attachments, which come under tension as the result of opposing forces exerted by microtubules. Tension is thought to stabilize these bi-oriented attachments indirectly, by suppressing the destabilizing activity of a kinas...

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Publisher copy:
10.1038/nature09594

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Sarangapani, KK More by this author
Powers, AF More by this author
Nelson, CR More by this author
Reichow, SL More by this author
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Journal:
Nature
Volume:
468
Issue:
7323
Pages:
576-579
Publication date:
2010-11-05
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:792208d0-ca7f-4dc9-9150-ba60303467fa
Source identifiers:
228691
Local pid:
pubs:228691

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