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The E3 ubiquitin ligase NEDD4 enhances killing of membrane-perturbing intracellular bacteria by promoting autophagy

Abstract:

The E3 ubiquitin ligase NEDD4 has been intensively studied in processes involved in viral infections, such as virus budding. However, little is known about its functions in bacterial infections. Our investigations into the role of NEDD4 in intracellular bacterial infections demonstrate that Mycobacterium tuberculosis and Listeria monocytogenes, but not Mycobacterium bovis BCG, replicate more efficiently in NEDD4 knockdown macrophages. In parallel, NEDD4 knockdown or knockout impaired basal ma...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1080/15548627.2017.1376160

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Oxford Ludwig Institute
Goosmann, C More by this author
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Grant:
Seventh Framework Program TBVAC2020 grant no. 643381
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Grant:
“inVAC” (grant no. 03ZZ0806A to S.H.E.K.)
Publisher:
Taylor & Francis Publisher's website
Journal:
Autophagy Journal website
Volume:
13
Issue:
12
Pages:
2041-2055
Publication date:
2017-12-17
Acceptance date:
2017-09-01
DOI:
EISSN:
1554-8635
ISSN:
1554-8627
Pubs id:
pubs:939831
URN:
uri:79117692-07cb-494d-a12c-29a494a8e38a
UUID:
uuid:79117692-07cb-494d-a12c-29a494a8e38a
Local pid:
pubs:939831

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