B cell survival, surface BCR and BAFFR expression, CD74 metabolism, and CD8- dendritic cells require the intramembrane endopeptidase SPPL2A. - Bergmann, H; Yabas, M; Short, A; Miosge, L; Barthel, N; Teh, C; Roots, C; Bull, K; Jeelall, Y; Horikawa, K; Whittle, B; Balakishnan, B; et al. (Journal of experimental medicine, 2013)