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Protein interactions in human genetic diseases.

Abstract:

We present a novel method that combines protein structure information with protein interaction data to identify residues that form part of an interaction interface. Our prediction method can retrieve interaction hotspots with an accuracy of 60% (at a 20% false positive rate). The method was applied to all mutations in the Online Mendelian Inheritance in Man (OMIM) database, predicting 1,428 mutations to be related to an interaction defect. Combining predicted and hand-curated sets, we discuss...

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Publisher copy:
10.1186/gb-2008-9-1-r9

Authors


Schuster-Böckler, B More by this author
Bateman, A More by this author
Journal:
Genome biology
Volume:
9
Issue:
1
Pages:
R9
Publication date:
2008
DOI:
EISSN:
1465-6914
ISSN:
1465-6906
URN:
uuid:7902faca-723e-4977-ba7f-0a2ffe161daf
Source identifiers:
410266
Local pid:
pubs:410266

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