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Journal article

Changes of 5-hydroxymethylcytosine distribution during myeloid and lymphoid differentiation of CD34+ cells

Abstract:

Background

Hematopoietic stem cell renewal and differentiation are regulated through epigenetic processes. The conversion of 5-methylcytosine into 5-hydroxymethylcytosine (5hmC) by ten-eleven-translocation enzymes provides new insights into the epigenetic regulation of gene expression during development. Here, we studied the potential gene regulatory role of 5hmC during human hematopoiesis.

Results

We used reduced representation of 5-hydroxymethylcytosine profilin...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/s13072-016-0070-8

Authors


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Role:
Author
ORCID:
0000-0003-2931-3652
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Role:
Author
ORCID:
0000-0003-3959-7409
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Publisher:
BioMed Central Publisher's website
Journal:
Epigenetics and Chromatin Journal website
Volume:
9
Issue:
1
Pages:
21
Publication date:
2016-05-31
Acceptance date:
2016-05-20
DOI:
EISSN:
1756-8935
ISSN:
1756-8935
Pubs id:
pubs:817478
URN:
uri:7900c90f-0188-4ae1-b84c-79eebc481a31
UUID:
uuid:7900c90f-0188-4ae1-b84c-79eebc481a31
Local pid:
pubs:817478

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