Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus.

Lawrenson, K; Kar, S; McCue, K; Kuchenbaeker, K; Michailidou, K; Tyrer, J; Beesley, J; Ramus, SJ; Li, Q; Delgado, MK; Lee, JM; Aittomäki, K; Andrulis, IL; Anton-Culver, H; Arndt, V; Arun, BK; Arver, B; Bandera, EV; Barile, M; Barkardottir, RB; Barrowdale, D; Beckmann, MW; Benitez, J; Berchuck, A; Bisogna, M; Bjorge, L; Blomqvist, C; Blot, W; Bogdanova, N; Bojesen, A; Bojesen, SE; Bolla, MK; Bonanni, B; Børresen-Dale, AL; Brauch, H; Brennan, P; Brenner, H; Bruinsma, F; Brunet, J; Buhari, SA; Burwinkel, B; Butzow, R; Buys, SS; Cai, Q; Caldes, T; Campbell, I; Canniotto, R; Chang-Claude, J; Chiquette, J; Choi, JY; Claes, KB; Cook, LS; Cox, A; Cramer, DW; Cross, SS; Cybulski, C; Czene, K; Daly, MB; Damiola, F; Dansonka-Mieszkowska, A; Darabi, H; Dennis, J; Devilee, P; Diez, O; Doherty, JA; Domchek, SM; Dorfling, CM; Dörk, T; Dumont, M; Ehrencrona, H; Ejlertsen, B; Ellis, S; Engel, C; Lee, E; Evans, DG; Fasching, PA; Feliubadalo, L; Figueroa, J; Flesch-Janys, D; Fletcher, O; Flyger, H; Foretova, L; Fostira, F; Foulkes, WD; Fridley, BL; Friedman, E; Frost, D; Gambino, G; Ganz, PA; Garber, J; García-Closas, M; Gentry-Maharaj, A; Ghoussaini, M; Giles, GG; Glasspool, R; Godwin, AK; Goldberg, MS; Goldgar, DE; González-Neira, A; Goode, EL; Goodman, MT; Greene, MH; Gronwald, J; Guénel, P; Haiman, CA; Hall, P; Hallberg, E; Hamann, U; Hansen, TV; Harrington, PA; Hartman, M; Hassan, N; Healey, S; Heitz, F; Herzog, J; Høgdall, E; Høgdall, CK; Hogervorst, FB; Hollestelle, A; Hopper, JL; Hulick, PJ; Huzarski, T; Imyanitov, EN; Isaacs, C; Ito, H; Jakubowska, A; Janavicius, R; Jensen, A; John, EM; Johnson, N; Kabisch, M; Kang, D; Kapuscinski, M; Karlan, BY; Khan, S; Kiemeney, LA; Kjaer, SK; Knight, JA; Konstantopoulou, I; Kosma, VM; Kristensen, V; Kupryjanczyk, J; Kwong, A; de la Hoya, M; Laitman, Y; Lambrechts, D; Le, N; De Leeneer, K; Lester, J; Levine, DA; Li, J; Lindblom, A; Long, J; Lophatananon, A; Loud, JT; Lu, K; Lubinski, J; Mannermaa, A; Manoukian, S; Le Marchand, L; Margolin, S; Marme, F; Massuger, LF; Matsuo, K; Mazoyer, S; McGuffog, L; McLean, C; McNeish, I; Meindl, A; Menon, U; Mensenkamp, AR; Milne, RL; Montagna, M; Moysich, KB; Muir, K; Mulligan, AM; Nathanson, KL; Ness, RB; Neuhausen, SL; Nevanlinna, H; Nord, S; Nussbaum, RL; Odunsi, K; Offit, K; Olah, E; Olopade, OI; Olson, JE; Olswold, C; O'Malley, D; Orlow, I; Orr, N; Osorio, A; Park, SK; Pearce, CL; Pejovic, T; Peterlongo, P; Pfeiler, G; Phelan, CM; Poole, EM; Pylkäs, K; Radice, P; Rantala, J; Rashid, MU; Rennert, G; Rhenius, V; Rhiem, K; Risch, HA; Rodriguez, G; Rossing, MA; Rudolph, A; Salvesen, HB; Sangrajrang, S; Sawyer, EJ; Schildkraut, JM; Schmidt, MK; Schmutzler, RK; Sellers, TA; Seynaeve, C; Shah, M; Shen, CY; Shu, XO; Sieh, W; Singer, CF; Sinilnikova, OM; Slager, S; Song, H; Soucy, P; Southey, MC; Stenmark-Askmalm, M; Stoppa-Lyonnet, D; Sutter, C; Swerdlow, A; Tchatchou, S; Teixeira, MR; Teo, SH; Terry, KL; Terry, MB; Thomassen, M; Tibiletti, MG; Tihomirova, L; Tognazzo, S; Toland, AE; Tomlinson, I; Torres, D; Truong, T; Tseng, CC; Tung, N; Tworoger, SS; Vachon, C; van den Ouweland, AM; van Doorn, HC; van Rensburg, EJ; Veer, LJ; Vanderstichele, A; Vergote, I; Vijai, J; Wang, Q; Wang-Gohrke, S; Weitzel, JN; Wentzensen, N; Whittemore, AS; Wildiers, H; Winqvist, R; Wu, AH; Yannoukakos, D; Yoon, SY; Yu, JC; Zheng, W; Zheng, Y; Khanna, KK; Simard, J; Monteiro, AN; French, JD; Couch, FJ; Freedman, ML; Easton, DF; Dunning, AM; Pharoah, PD; Edwards, SL; Chenevix-Trench, G; Antoniou, AC; Gayther, SA

Journal article

Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus.

Abstract:: A locus at 19p13 is associated with breast cancer (BC) and ovarian cancer (OC) risk. Here we analyse 438 SNPs in this region in 46,451 BC and 15,438 OC cases, 15,252 BRCA1 mutation carriers and 73,444 controls and identify 13 candidate causal SNPs associated with serous OC (P=9.2 × 10(-20)), ER-negative BC (P=1.1 × 10(-13)), BRCA1-associated BC (P=7.7 × 10(-16)) and triple negative BC (P-diff=2 × 10(-5)). Genotype-gene expression associations are identified for candidate target genes ANKLE1 (...
Expand abstract
Collapse abstract

Publication status:: Published

Peer review status:: Peer reviewed

Actions

Email

Email this record

Send the bibliographic details of this record to your email address.

Your Email
Please enter the email address that the record information will be sent to.

-
Your message (optional)
Please add any additional information to be included within the email.
Cite

Cite this record

APA Style

Lawrenson, K., Kar, S., McCue, K., Kuchenbaeker, K., Michailidou, K., Tyrer, J., Beesley, J., Ramus, S. J., Li, Q., Delgado, M. K., Lee, J. M., Aittomäki, K., Andrulis, I. L., Anton-Culver, H., Arndt, V., Arun, B. K., Arver, B., Bandera, E. V., Barile, M., … Gayther, S. A. (2016). Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus. Nature Communications, 7, 12675.

MLA Style

Lawrenson, K., et al. “Functional Mechanisms Underlying Pleiotropic Risk Alleles at the 19p13.1 Breast-Ovarian Cancer Susceptibility Locus.” Nature Communications, vol. 7, Nature Publishing Group, 2016, p. 12675.

Chicago Style

Lawrenson, K, S Kar, K McCue, K Kuchenbaeker, K Michailidou, J Tyrer, J Beesley, et al. 2016. “Functional Mechanisms Underlying Pleiotropic Risk Alleles at the 19p13.1 Breast-Ovarian Cancer Susceptibility Locus.” Nature Communications 7: 12675.
Tweet
Print

Access Document

Files:: Functional mechanisms underlying pleiotropic risk alleles at t...

(Preview, Version of record, pdf, 1.6MB, Terms of use)

Publisher copy:: 10.1038/ncomms12675

Authors

+ Lawrenson, K More by this author

Role:

Author

+ Kar, S More by this author

Role:

Author

+ McCue, K More by this author

Role:

Author

+ Kuchenbaeker, K More by this author

Role:

Author

+ Michailidou, K More by this author

Role:

Author

More authors...

Funding

+ /Cancer Research UK More from this funder

Grant:

20861

+ Medical Research Council More from this funder

Grant:

1515685

+ National Institutes of Health More from this funder

Grant:

UM1 CA182910

+ Ovarian Cancer Action More from this funder

Bibliographic Details

Publisher:: Nature Publishing Group
Journal:: Nature Communications More from this journal
Volume:: 7
Pages:: 12675
Publication date:: 2016-09-01
Acceptance date:: 2016-07-20
DOI:: 10.1038/ncomms12675
EISSN:: 2041-1723
Pmid:: 27601076

Item Description

Language:: English
Keywords:: EMBRACE

GEMO Study Collaborators

Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON)

KConFab Investigators

Australian Ovarian Cancer Study Group
Pubs id:: pubs:641721
UUID:: uuid:78fda653-a6ba-4d12-bbc7-c528a492090c
Local pid:: pubs:641721
Source identifiers:: 641721
Deposit date:: 2017-08-25

Terms of use

Copyright holder:: Tomlinson et al
Notes:: © The Author(s) 2016. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

Licence:: CC Attribution (CC BY)

Metrics

Views and Downloads

About views and downloads

If you are the owner of this record, you can report an update to it here: Report update to this record

Journal article

Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus.

Actions

Access Document

Authors

Funding

Bibliographic Details

Item Description

Terms of use

Metrics

Views and Downloads

Altmetrics

Dimensions