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Splicing of many human genes involves sites embedded within introns.

Abstract:

The conventional model for splicing involves excision of each intron in one piece; we demonstrate this inaccurately describes splicing in many human genes. First, after switching on transcription of SAMD4A, a gene with a 134 kb-long first intron, splicing joins the 3' end of exon 1 to successive points within intron 1 well before the acceptor site at exon 2 is made. Second, genome-wide analysis shows that>60% of active genes yield products generated by such intermediate intron splicing. Th...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/nar/gkv386

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Institution:
University of Oxford
Department:
Oxford, MPLS, Plant Sciences
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
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Funding agency for:
Kelly, S
Federal Ministry for Education and Research More from this funder
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Publisher:
Oxford University Press Publisher's website
Journal:
Nucleic Acids Research Journal website
Volume:
43
Issue:
9
Pages:
4721-4732
Publication date:
2015-05-05
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
URN:
uuid:78fd8130-1420-43b9-91ef-0921dabc44e2
Source identifiers:
518816
Local pid:
pubs:518816

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