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Severe polyposis in Apc1322T mice is associated with submaximal Wnt signalling and increased expression of the stem cell marker Lgr5

Abstract:

Background and aims: Adenomatous polyposis coli (APC) is a tumour suppressor gene mutated in the germline of patients with familial adenomatous polyposis (FAP) and somatically in most colorectal cancers. APC mutations impair β-catenin degradation, resulting in increased Wnt signalling. The most frequent APC mutation is a codon 1309 truncation that is associated with severe FAP. A previous study compared two mouse models of intestinal tumorigenesis, ApcR850X (Min) and. Apc1322T (1322T), the la...

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Publisher copy:
10.1136/gut.2009.193680

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Journal:
Gut
Volume:
59
Issue:
12
Pages:
1680-1686
Publication date:
2010-12-05
DOI:
EISSN:
1468-3288
ISSN:
0017-5749
URN:
uuid:78f33206-e684-45a5-861a-9b777e25b7e9
Source identifiers:
107193
Local pid:
pubs:107193
Language:
English

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