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Apomorphine-induced yawning in rats is abolished by bilateral 6-hydroxydopamine lesions of the substantia nigra.

Abstract:

Apomorphine-induced yawning was studied in male rats with bilateral 6-hydroxydopamine lesions of the substantia nigra. Apomorphine 10, 20 and 50 micrograms/kg SC induced dose-dependent yawning in unoperated controls and animals with sham lesions. In the lesioned animals (in which the mean striatal dopamine depletion was 67%), the maximum yawning response rate was greatly attenuated with no evidence that the dose response curve was shifted in either direction. Furthermore, blockade of yawning ...

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Publication status:
Published

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Publisher copy:
10.1007/bf00187253

Authors


Stoessl, AJ More by this author
Dourish, CT More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
Journal:
Psychopharmacology
Volume:
93
Issue:
3
Pages:
336-342
Publication date:
1987
DOI:
EISSN:
1432-2072
ISSN:
0033-3158
URN:
uuid:78e4b60c-e773-4ec5-9676-78f21ffe81d6
Source identifiers:
22060
Local pid:
pubs:22060

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