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Thesis

Regulation of exosome secretion and functions by mTORC1 signalling and the microenvironment

Abstract:

Cancer cells require survival strategies to respond to microenviromental changes and out-compete their neighbours. They activate stress response mechanisms under extreme microenvironmental conditions, some of which are controlled by the amino acid-sensitive kinase complex, mechanistic Target of Rapamycin Complex 1 (mTORC1). Exosomes are secreted nanovesicles made inside intracellular endosomal compartments that mediate a specialised and complex form of intercellular signalling that can rep...

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Mihindukulasuriya Weliweriyage Sumeth Perera More by this author

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Role:
Examiner
Role:
Examiner
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Supervisor
Role:
Supervisor
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Funding agency for:
Mihindukulasuriya Weliweriyage Sumeth Perera
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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