Proximal tubular cell sodium concentration in early diabetic nephropathy assessed by electron microprobe analysis.

Journal article

Electron microprobe X-ray analysis techniques were employed in order to assess the changes that occur in proximal tubular cell sodium concentration during the hyperfiltration phase of early diabetes mellitus induced by streptozotocin in Sprague Dawley rats. Intracellular rubidium accumulation following intravenous infusion of rubidium chloride was used as a marker of basolateral Na/K-ATPase activity. The diabetic animals studied had a significantly higher glomerular filtration rate compared w...

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Authors: Pollock, C; Field, M; Bostrom, T; Dyne, M; Gyory, A

• Publication status: Published
• Journal: Pflugers Archiv : European journal of physiology
• Volume: 418
• Issue: 1-2
• Pages: 14-17
• Publication date: 1991-03-01
• DOI: 10.1007/bf00370446
• EISSN: 1432-2013
• ISSN: 0031-6768
• Language: English
• Keywords: Sodium-Potassium-Exchanging ATPase; Diabetes Mellitus, Experimental; Kidney Tubules, Proximal; Diabetic Nephropathies; Animals; Rats; Electron Probe Microanalysis; Sodium; Rats, Inbred Strains; Male