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Proximal tubular cell sodium concentration in early diabetic nephropathy assessed by electron microprobe analysis.

Abstract:

Electron microprobe X-ray analysis techniques were employed in order to assess the changes that occur in proximal tubular cell sodium concentration during the hyperfiltration phase of early diabetes mellitus induced by streptozotocin in Sprague Dawley rats. Intracellular rubidium accumulation following intravenous infusion of rubidium chloride was used as a marker of basolateral Na/K-ATPase activity. The diabetic animals studied had a significantly higher glomerular filtration rate compared w...

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Publication status:
Published

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Publisher copy:
10.1007/bf00370446

Authors


Pollock, CA More by this author
Bostrom, TE More by this author
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Journal:
Pflugers Archiv : European journal of physiology
Volume:
418
Issue:
1-2
Pages:
14-17
Publication date:
1991-03-05
DOI:
EISSN:
1432-2013
ISSN:
0031-6768
URN:
uuid:78df8c49-237c-4a03-b533-8f55f9901148
Source identifiers:
27834
Local pid:
pubs:27834

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