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Limiting dilution analysis of helper T-cell function.

Abstract:

Limiting dilution analysis has been applied to the study of T-cell 'helper' function in vitro. Using the microculture system one can estimate the numbers of (a) 'helper' T cells involved in specific collaboration with B cells and (b) those T cells which are able, on being activated by their specific antigen, to facilitate the response of B cells to another antigen. Such studies have enabled us to demonstrate that: (1) a single 'helper' T cell was able to activate a single B-cell precursor to ...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Lefkovits, I More by this author
Quintáns, J More by this author
Journal:
Immunology
Volume:
28
Issue:
6
Pages:
1135-1148
Publication date:
1975-06-05
EISSN:
1365-2567
ISSN:
0019-2805
URN:
uuid:78dd34d2-7041-472e-8675-cce45d42a7e1
Source identifiers:
9210
Local pid:
pubs:9210

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