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The key hypoxia regulated gene CAIX is upregulated in basal-like breast tumours and is associated with resistance to chemotherapy.

Abstract:

Basal-like tumours account for 15% of invasive breast carcinomas and are associated with a poorer prognosis and resistance to therapy. We hypothesised that this aggressive phenotype is because of an intrinsically elevated hypoxic response. Microarrayed tumours from 188 patients were stained for hypoxia-inducible factor (HIF)-1alpha, prolyl hydroxylase (PHD)1, PHD2, PHD3 and factor inhibiting HIF (FIH)-1, and carbonic anhydrase (CA) IX stained in 456 breast tumours. Tumour subtypes were correl...

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Publication status:
Published

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Publisher copy:
10.1038/sj.bjc.6604844

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Journal:
British journal of cancer
Volume:
100
Issue:
2
Pages:
405-411
Publication date:
2009-01-05
DOI:
EISSN:
1532-1827
ISSN:
0007-0920
URN:
uuid:78ca167d-77b9-4740-a82d-77bd9a26e468
Source identifiers:
119440
Local pid:
pubs:119440

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