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Frequency domain analysis of small non-coding RNAs shows summing junction-like behaviour

Abstract:

Small non-coding RNAs (sRNA) are a key bacterial regulatory mechanism that has yet to be fully exploited in synthetic gene regulatory networks. In this paper a linear design methodology for gene regulatory networks presented previously is extended for application to sRNAs. Standard models of both sRNA inhibition and activation are presented, linearised and transformed into the frequency domain. We demonstrate how these mechanisms can emulate subtraction and minimum comparator functions in spe...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1109/CDC.2017.8264448

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Institution:
University of Oxford
Division:
MPLS Division
Department:
Engineering Science
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Engineering Science
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Engineering Science
Oxford college:
Worcester College
Role:
Author
ORCID:
0000-0002-3565-8967
General Sir John Monash Foundation More from this funder
Publisher:
Institute for Electrical and Electronics Engineers Publisher's website
Publication date:
2018-01-23
Acceptance date:
2017-07-12
DOI:
ISSN:
0743-1546
Pubs id:
pubs:827469
URN:
uri:78bf0e95-ae8d-4ccd-af38-bc4b309e7ca7
UUID:
uuid:78bf0e95-ae8d-4ccd-af38-bc4b309e7ca7
Local pid:
pubs:827469
ISBN:
9781509028733

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