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Journal article

Profound and selective loss of catalytic TrkB immunoreactivity in Alzheimer's disease.

Abstract:

Brain-derived neurotrophic factor (BDNF) is known to have trophic effects on various neurons, throughout the brain and spinal cord, via its high-affinity tyrosine kinase receptor TrkB. It has been reported that the mRNA for this neurotrophin is reduced in Alzheimer's disease (AD) brain. We have examined, by Western blotting, the catalytic (p145) and noncatalytic or truncated (p95) forms of TrkB and find that, in both the temporal and frontal cortex, there is a selective loss of immunoreactive...

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Publication status:
Published

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Publisher copy:
10.1006/bbrc.1999.1561

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Dawbarn, D More by this author
Journal:
Biochemical and biophysical research communications
Volume:
264
Issue:
3
Pages:
648-651
Publication date:
1999-11-05
DOI:
EISSN:
1090-2104
ISSN:
0006-291X
URN:
uuid:78bc71ff-6b21-4fea-bc39-1137d3e49100
Source identifiers:
31566
Local pid:
pubs:31566

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