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Thesis

The role of IGF-1R signaling in the DNA damage response of prostate cancer

Abstract:

The type 1 insulin like growth factor receptor (IGF-1R) is a cell surface receptor that mediates proliferation and cell survival. The aim of this project was to explore the contribution of the IGF-1R to the DNA damage response in human prostate cancer cells. Previous work from our group showed IGF-1R to be over expressed in prostate cancer. Furthermore, IGF-1R depletion enhances sensitivity of prostate cancer cells to DNA damaging agents, and IGF-1R depletion or inhibition delays DSB re...

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Institution:
University of Oxford
Research group:
Growth Factor Group
Oxford college:
Oriel College
Department:
Medical Sciences Division

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Role:
Supervisor
Role:
Supervisor
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Funding agency for:
Kunal Lodhia
Publication date:
2013-03-05
Type of award:
DPhil
Level of award:
Doctoral

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