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Vascular wall regulator of G-protein signalling-1 (RGS-1) is required for angiotensin II–mediated blood pressure control

Abstract:

G-Protein coupled receptors (GPCRs) activate intracellular signalling pathways by coupling to heterotrimeric G-proteins that control many physiological processes including blood pressure homeostasis. The Regulator of G-Protein Signalling-1 (RGS1) controls the magnitude and duration of downstream GPCR signalling by acting as a GTPase-activating protein for specific Gα-proteins. RGS1 has contrasting roles in haematopoietic and non-haematopoietic cells. Rgs1−/−ApoE−/− mice are protected from Ang...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.vph.2018.04.002

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; OCDEM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; RDM Cardiovascular Medicine
Role:
Author
More from this funder
Grant:
091504/Z/10/Z and 090532/Z/09/Z
More from this funder
Grant:
Oxford Biomedical Research Centre
Publisher:
Elsevier Publisher's website
Journal:
Vascular Pharmacology Journal website
Volume:
108
Pages:
15-22
Publication date:
2018-04-11
Acceptance date:
2018-04-05
DOI:
ISSN:
1537-1891
Pubs id:
pubs:835367
URN:
uri:78b599db-85e8-4b27-ac13-9a56fddc44b4
UUID:
uuid:78b599db-85e8-4b27-ac13-9a56fddc44b4
Local pid:
pubs:835367

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