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Reactive oxygen species and p38 mitogen-activated protein kinase mediate tumor necrosis factor α-converting enzyme (TACE/ADAM-17) activation in primary human monocytes.

Abstract:

Tumor necrosis factor α-converting enzyme (TACE) is responsible for the shedding of cell surface TNF. Studies suggest that reactive oxygen species (ROS) mediate up-regulation of TACE activity by direct oxidization or modification of the protein. However, these investigations have been largely based upon nonphysiological stimulation of promonocytic cell lines which may respond and process TACE differently from primary cells. Furthermore, investigators have relied upon TACE substrate shedding a...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m111.277434

Authors


O'Callaghan, D More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Dokpesi, JO More by this author
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Journal:
The Journal of biological chemistry
Volume:
286
Issue:
41
Pages:
35466-35476
Publication date:
2011-10-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:78b16151-a6d4-40a3-982a-2c8fff5591de
Source identifiers:
230421
Local pid:
pubs:230421

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