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Direct ex vivo analysis reveals distinct phenotypic patterns of HIV-specific CD8(+) T lymphocyte activation in response to therapeutic manipulation of virus load.

Abstract:

Therapeutic intervention with antiretroviral therapy (ART) enables the modulation of HIV virus load and hence provides a unique opportunity to study the consequences of varying antigen load on the phenotype of virus-specific CD8(+) T lymphocytes in a persistent human viral infection. The recent advent of tetrameric peptide / HLA class I complexes has enabled the direct phenotypic characterization of antigen-specific T cell populations ex vivo. Here, we use this technology to examine directly ...

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Publication status:
Published

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Journal:
European journal of immunology
Volume:
31
Issue:
4
Pages:
1115-1121
Publication date:
2001-04-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:78afbac4-7c8b-48ad-a405-20d4a05c55e2
Source identifiers:
2832
Local pid:
pubs:2832

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