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Helix kinks are equally prevalent in soluble and membrane proteins.

Abstract:

Helix kinks are a common feature of α-helical membrane proteins, but are thought to be rare in soluble proteins. In this study we find that kinks are a feature of long α-helices in both soluble and membrane proteins, rather than just transmembrane α-helices. The apparent rarity of kinks in soluble proteins is due to the relative infrequency of long helices (≥20 residues) in these proteins. We compare length-matched sets of soluble and membrane helices, and find that the frequency of kinks, th...

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Publication status:
Published

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Publisher copy:
10.1002/prot.24550

Authors


Wilman, HR More by this author
Journal:
Proteins
Volume:
82
Issue:
9
Pages:
1960-1970
Publication date:
2014-09-05
DOI:
EISSN:
1097-0134
ISSN:
0887-3585
URN:
uuid:789fc473-843c-4e90-ad71-cc2e6032d8c1
Source identifiers:
462276
Local pid:
pubs:462276

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