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Journal article

Maternal high-fat diet interacts with embryonic Cited2 genotype to reduce Pitx2c expression and enhance penetrance of left-right patterning defects.

Abstract:

Deficiency of the transcription factor Cited2 in mice results in cardiac malformation, adrenal agenesis, neural tube, placental defects and partially penetrant cardiopulmonary laterality defects resulting from an abnormal Nodal->Pitx2c pathway. Here we show that a maternal high-fat diet more than doubles the penetrance of laterality defects and, surprisingly, induces palatal clefting in Cited2-deficient embryos. Both maternal diet and Cited2 deletion reduce embryo weight and kidney and thy...

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Publication status:
Published

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Publisher copy:
10.1093/hmg/ddq251

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Cardiovascular Medicine
Michell, AC More by this author
Lockstone, H More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Cardiovascular Medicine, BHF Centre of Research Excellence
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Journal:
Human molecular genetics
Volume:
19
Issue:
17
Pages:
3394-3401
Publication date:
2010-09-05
DOI:
EISSN:
1460-2083
ISSN:
0964-6906
URN:
uuid:78952934-905a-4307-b95d-9ac7a67222a5
Source identifiers:
105186
Local pid:
pubs:105186

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