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Journal article

CD8 independence and specificity of cytotoxic T lymphocytes restricted by HLA-Aw68.1.

Abstract:

The crystal structure of the HLA-Aw68.1 antigen binding site revealed a negatively charged pocket centred on aspartic acid 74 (Garrett et al. 1989). Access to this '74 pocket' is blocked in HLA-Aw68.2 and HLA-Aw69 by two substitutions at positions 97 and 116. This key feature suggests that the Aw68.1-peptide-specific interactions may involve salt bridges between oppositely charged residues. In this paper, the influenza epitope recognized by virus-specific HLA-Aw68.1-restricted cytotoxic T lym...

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Publication status:
Published

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Publisher copy:
10.1098/rspb.1991.0066

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine, Biomedical Research Centre
Salter, RD More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine
Journal:
Proceedings. Biological sciences / The Royal Society
Volume:
244
Issue:
1310
Pages:
169-177
Publication date:
1991-05-05
DOI:
EISSN:
1471-2954
ISSN:
0962-8452
URN:
uuid:788e2fd8-7f57-4b30-810f-5a4e2351118a
Source identifiers:
33700
Local pid:
pubs:33700

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