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School-aged children: a reservoir for continued circulation of Haemophilus influenzae Type b in the United Kingdom

Abstract:

Background: A resurgence of Haemophilus influenzae type b (Hib) disease occurred in the United Kingdom between 1999 and 2003 and was partially attributed to lower immunogenicity of combination vaccines. The reservoir for Hib that led to transmission in this period is unknown. Methods: We estimated the point prevalence of Hib carriage in school-aged children and adults, using oropharyngeal swabbing and selective media. We characterized the Hib isolates by multilocus sequence typing (M...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1086/586716

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Institution:
University of Oxford
Research group:
Oxford Vaccine Group
Department:
Medical Sciences Division - Paediatrics,Department of
Role:
Author
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Institution:
"John Radcliffe Hospital, Oxford"
Department:
Department of Microbiology
Role:
Author
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Institution:
University of Oxford
Research group:
Oxford Vaccine Group
Department:
Medical Sciences Division - Paediatrics,Department of
Role:
Author
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Institution:
University of Oxford
Research group:
Oxford Vaccine Group
Department:
Medical Sciences Division - Paediatrics,Department of
Role:
Author
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Institution:
University of Oxford
Department:
Centre for Statistics in Medicine
Role:
Author
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Funding agency for:
E. Richard Moxon
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Funding agency for:
A. J. Pollard
Publisher:
University of Chicago Press Publisher's website
Journal:
Journal of Infectious Diseases Journal website
Volume:
197
Issue:
9
Pages:
1275-1281
Publication date:
2008-05-05
DOI:
ISSN:
0022-1899
URN:
uuid:78808e5b-4b42-4977-9d12-a2ef0649f106
Local pid:
ora:3047

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