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Loss of 5α-reductase type 1 accelerates the development of hepatic steatosis but protects against hepatocellular carcinoma in male mice.

Abstract:

Nonalcoholic fatty liver disease (NAFLD) has been associated with glucocorticoid excess and androgen deficiency, yet in the majority of patients with steatohepatitis, circulating cortisol and androgen levels are normal. The enzyme 5α-reductase (5αR) has a critical role in androgen and glucocorticoid action. We hypothesize that 5αR has an important role in the pathogenesis of steatohepatitis through regulation of intracrine/paracrine hormone availability. Human liver samples from patients with...

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Publication status:
Published

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Publisher copy:
10.1210/en.2013-1592

Authors


Dowman, JK More by this author
Hopkins, LJ More by this author
Reynolds, GM More by this author
Armstrong, MJ More by this author
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Journal:
Endocrinology
Volume:
154
Issue:
12
Pages:
4536-4547
Publication date:
2013-12-05
DOI:
EISSN:
1945-7170
ISSN:
0013-7227
URN:
uuid:786e3731-5222-4444-ac57-b743e0af9dfa
Source identifiers:
482055
Local pid:
pubs:482055

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