Journal article icon

Journal article

Ribonuclease inhibitor 1 regulates erythropoiesis by controlling GATA1 mRNA translation

Abstract:

Ribosomal proteins (RP) regulate specific gene expression by selectively translating subsets of mRNAs. Indeed, in Diamond–Blackfan anaemia and 5q- syndrome, mutations in RP genes lead to a specific defect in erythroid gene translation and cause anaemia. Little is known about the molecular mechanisms of selective mRNA translation and involvement of ribosomal-associated factors in this process. Ribonuclease inhibitor (RNH1) is an ubiquitously expressed protein that binds to and inhibits panc...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.1172/JCI94956

Authors


Chennupati, V More by this author
Veiga, DFT More by this author
Maslowski, KM More by this author
Tardivel, A More by this author
Expand authors...
Louis Jeantet Foundation More from this funder
Institute for Arthritis Research More from this funder
Publisher:
American Society for Clinical Investigation Publisher's website
Journal:
Journal of Clinical Investigation Journal website
Volume:
128
Issue:
4
Pages:
1597-1614
Publication date:
2018-02-06
Acceptance date:
2018-01-16
DOI:
EISSN:
1558-8238
ISSN:
0021-9738
Pubs id:
pubs:829314
URN:
uri:7862cd10-a032-4cce-a6b2-543ddff31131
UUID:
uuid:7862cd10-a032-4cce-a6b2-543ddff31131
Local pid:
pubs:829314

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP